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Association analysis of the of the rs1466662 polymorphic variant in the DCHS2 gene with personal characteristics of students determined by sixteen Сatell factor questionnaire (16PF)
https://doi.org/10.25557/2073-7998.2025.07.57-60
Abstract
The goal is to identify personality factors associated with a polymorphic marker of susceptibility to Alzheimer’s disease. The relationship between quantitative character traits determined using Cattell’s psychodiagnostic method (16 factor personality questionnaire, 16PF) and the polymorphic variant rs1466662 in the DCHS2 gene was analyzed. DNA samples from 172 students were genotyped by MALDI-TOF mass spectrometry. The obtained data were processed by the nonparametric Kruskal-Wallis test. Non-random associations were established with factor A (withdrawal – sociability) in the general sample of medical university students under a codominant type of inheritance (р = 0.018). A connection was found between this variant and factor F (restraint – expressiveness) for an autosomal recessive type of inheritance (р = 0.016) in males, and factor F4 (conformity – independence) under an overdominant type of inheritance (р = 0.031) in females. The findings likely indicate a partially overlapping genetic component of susceptibility to Alzheimer’s disease and variability in personality traits.
Keywords
Supporting agencies: The study was carried out with the financial support of project No. 20-015-00397 of the Russian Foundation for Basic Research.
About the Authors
A. V. Marusin
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050
A. N. Kornetov
Siberian State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
2, Moscow tract, Tomsk, 634055
M. G. Svarovskaya
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050
A. V. Bocharova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050
V. A. Stepanov
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050
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Review
For citations:
Marusin A.V., Kornetov A.N., Svarovskaya M.G., Bocharova A.V., Stepanov V.A. Association analysis of the of the rs1466662 polymorphic variant in the DCHS2 gene with personal characteristics of students determined by sixteen Сatell factor questionnaire (16PF). Medical Genetics. 2025;24(7):57-60. (In Russ.) https://doi.org/10.25557/2073-7998.2025.07.57-60
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