Some molecular genetic markers of obesity in women

Abstract

Obesity is a serious social and medical problem. The study is conducted on the basis of the population sample of the HAPIEE project. Groups of women were formed, selected by body mass index (BMI) using WHO criteria. Approximately 100 people in each group, starting from 18.5-25 kg/m². Age 45-69 years (n=520). 11 nucleotide sequence variants (NSVs) were genotyped: rs9939609 FTO, rs17782313 MOC4R, rs3810291 ZC3H4, rs7903146 TCF7L2, rs1799883 FABP2, rs1800497 DRD2, rs12940622 RPTOR, rs1800437 GIPR, rs1561589 CTBP2, rs6773957 ADIPOQ, rs13021737 chr. 2. Genotype frequencies were analyzed in groups with different BMI, body roundness index (BRI), morbid obesity (MO), and abdominal obesity (AO). Significant differences were obtained in the groups of women divided by BMI by genotype frequencies: rs9939609, rs17782313, rs3810291, rs12940622, rs1800437, rs7903146. Significant associations with the body roundness index were obtained: rs9939609, rs17782313, rs3810291, rs12940622, rs7903146. rs9939609, rs12940622 were associated with abdominal obesity. Associated with morbid obesity: rs9939609, rs12940622, rs1561589. Conclusion. rs9939609, rs17782313, rs3810291, rs12940622, rs1800437, rs13021737, rs1561589, rs7903146 are associated with different obesity phenotypes in women in the urban Caucasian population.