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Analysis of cardiovascular risk genes polymorphism in workers in hazardous industries
https://doi.org/10.25557/2073-7998.2025.07.34-36
Abstract
The relationship of the polymorphic genes AGT (rs699), eNOS (rs2070744), AGTR1 (rs5186), and AGT (rs4762) and cardiovascular risk in workers in the mechanical engineering industry was analyzed. It has been shown that in women exposed to harmful occupational factors such as noise, vibration and severity of labour in excess of hygienic standards, the A/C genotype of the rs5186 polymorphic variant demonstrates a protective effect on the risk of developing hypertension (OR = 0.09, 95% CI: 0.01 – 0.77 and OR = 0.08, 95% CI: 0.01 – 0.71, respectively). In men, the C/T polymorphic variant rs2070744 genotype increases the risk of hypertension when working in excessive noise and vibration (OR =6.21, 95%CI: (1.06-36.40), and in severity of labour (OR =6.14, 95%CI: (1.04-36.39).
About the Authors
O. V. Gorenskaya
Federal Scientific Center of Hygiene named after F.F. Erisman of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Russian Federation
Russian Federation
2, Semashko st., Mytishchi, 141014
A. P. Kotnova
Federal Scientific Center of Hygiene named after F.F. Erisman of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Russian Federation
Russian Federation
2, Semashko st., Mytishchi, 141014
O. V. Egorova
Federal Scientific Center of Hygiene named after F.F. Erisman of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Russian Federation
Russian Federation
2, Semashko st., Mytishchi, 141014
D. S. Gavrilchenko
Federal Scientific Center of Hygiene named after F.F. Erisman of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Russian Federation
Russian Federation
2, Semashko st., Mytishchi, 141014
M. G. Platoshkin
Federal Scientific Center of Hygiene named after F.F. Erisman of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Russian Federation
Russian Federation
2, Semashko st., Mytishchi, 141014
N. A. Ilyushina
Federal Scientific Center of Hygiene named after F.F. Erisman of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Russian Federation
Russian Federation
2, Semashko st., Mytishchi, 141014
References
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Review
For citations:
Gorenskaya O.V., Kotnova A.P., Egorova O.V., Gavrilchenko D.S., Platoshkin M.G., Ilyushina N.A. Analysis of cardiovascular risk genes polymorphism in workers in hazardous industries. Medical Genetics. 2025;24(7):34-36. (In Russ.) https://doi.org/10.25557/2073-7998.2025.07.34-36
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