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Clastogenic effect of nitrogen tetraoxide in acute inhalation poisoning
https://doi.org/10.25557/2073-7998.2025.06.30-32
Abstract
The analysis of genotoxic effect of potential mutagens in humans usually is carried out in chronic exposure industrial conditions, data on genotoxic effect of acute poisoning are practically absent, therefore the examination of really affected people is of special interest. The aim of the study is to investigate the level of chromosomal aberrations in the acute poisoned with nitrogen oxides workers of the rocket and space industry. The results of cytogenetic examination of 18 persons with nitrogen oxides acute inhalation poisoning during routine cleaning of a railroad tank car from amyl are presented. An increased level of unstable chromosomal aberrations was found, mainly due to a statistically significant increase in the frequency of chromatid-type aberrations. which are typical for chemical mutagenesis. These changes were detected after normalization of other laboratory parameters and clinical recovery of the victims. Thus, nonspecific chromosomal damages typical occur as a result of nitrogen oxides acute poisoning.
About the Authors
L. G. Arzhavkina
Military medical academy of S.M. Kirov; North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
6G, Akademika Lebedeva st., Saint-Petersburg, 194044; 41, Kirochnaya st., Saint-Petersburg, 191015
T. V. Kharchenko
Military medical academy of S.M. Kirov; North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
6G, Akademika Lebedeva st., Saint-Petersburg, 194044; 41, Kirochnaya st., Saint-Petersburg, 191015
A. V. Bolekhan
Military medical academy of S.M. Kirov
Russian Federation
Russian Federation
6G, Akademika Lebedeva st., Saint-Petersburg, 194044
E. G. Bogdanova
Military medical academy of S.M. Kirov
Russian Federation
Russian Federation
6G, Akademika Lebedeva st., Saint-Petersburg, 194044
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Review
For citations:
Arzhavkina L.G., Kharchenko T.V., Bolekhan A.V., Bogdanova E.G. Clastogenic effect of nitrogen tetraoxide in acute inhalation poisoning. Medical Genetics. 2025;24(6):30-32. (In Russ.) https://doi.org/10.25557/2073-7998.2025.06.30-32
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