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Gene pool of the Russian population of Siberia based on haplotypes of the VDR and NF-kB1 transcription factor genes
https://doi.org/10.25557/2073-7998.2025.05.99-101
Abstract
High research interest in the polymorphism of the VDR and NFKB genes is due to its ability to modify intracellular signaling, determine the adaptive potential of populations and affect the structure of population morbidity. The data of a study in a sample of the Russian population of Siberia of the frequencies of haplotypes of the VDR and NFKB1 genes for a panel of 13 SNPs are discussed. DNA isolated from blood samples (n = 96) was genotyped by real-time PCR. The result was the identification of 21 haplotype variants in the VDR and 33 in the NFKB1. The frequency and spectrum of major haplotypes recorded with a frequency of more than 20%, as well as common variants found in the gene pool of Russians in Siberia with a frequency of more than 5% and more than 1% were established. The data obtained characterize the gene pool of the Russian population of Siberia and can be used as a basis for subsequent studies.
Supporting agencies: The work was carried out within the framework of the state assignment of the Ministry of Health of the Russian Federation for KemSMU (Agreement No. 056-03-2023-050 dated 01/17/2023) and a grant from the Russian Science Foundation (No. 22-25-20209, https://rscf.ru/ project/22-25-20209) and the Ministry of Science and Higher Education of Kuzbass.
About the Authors
M. B. Lavryashina
Kemerovo State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
20а, Voroshilova st., Kemerovo, 650056, Russian Federation
B. A. Thorenko
Kemerovo State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
20а, Voroshilova st., Kemerovo, 650056, Russian Federation
A. V. Meyer
Kemerovo State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
20а, Voroshilova st., Kemerovo, 650056, Russian Federation
D. O. Imekina
Kemerovo State Medical University, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
20а, Voroshilova st., Kemerovo, 650056, Russian Federation
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Review
For citations:
Lavryashina M.B., Thorenko B.A., Meyer A.V., Imekina D.O. Gene pool of the Russian population of Siberia based on haplotypes of the VDR and NF-kB1 transcription factor genes. Medical Genetics. 2025;24(5):99-101. (In Russ.) https://doi.org/10.25557/2073-7998.2025.05.99-101
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