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Study of regulatory polymorphic variants of cytokine genes and their receptors with the development of bronchial asthma and tuberculosis
https://doi.org/10.25557/2073-7998.2025.05.82-83
Abstract
Bronchial asthma (BA) and pulmonary tuberculosis (TB) are multifactorial diseases and pose an important public health problem. Susceptibility to these diseases is based on both environmental and genetic factors, most of which are unknown. The study examined the association of 13 polymorphic variants of genes that affect the implementation of the immune response in samples of patients with BA, TB and in the control group. Two statistical algorithms were used: univariate analysis of associations and classification of genetic data using the decision tree algorithm. The study found that rs525891, rs2239704, rs16944, rs1800872, rs56061981 and rs4386624 variants are associated with TB, and rs2239704, rs652625 are associated with BA.
Supporting agencies: The research was supported by the Ministry of Science and Higher Education (No. 122020300041-7).
About the Authors
I. Zh. Zhalsanova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050, Russian Federation
A. A. Zarubin
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050, Russian Federation
N. P. Babushkina
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050, Russian Federation
E. Yu. Bragina
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050, Russian Federation
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For citations:
Zhalsanova I.Zh., Zarubin A.A., Babushkina N.P., Bragina E.Yu. Study of regulatory polymorphic variants of cytokine genes and their receptors with the development of bronchial asthma and tuberculosis. Medical Genetics. 2025;24(5):82-83. (In Russ.) https://doi.org/10.25557/2073-7998.2025.05.82-83
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