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Evaluation of the cyto- and genotoxicity of a fungicide from the phthalimide class
https://doi.org/10.25557/2073-7998.2025.05.80-81
Abstract
A fungicide from the phthalimide class exhibited cytotoxic and genotoxic effects on human peripheral blood lymphocytes in vitro. At the pesticide concentration of 2.5-25 μg/ml, an increase in the pool of cells in late apoptosis and necrosis was observed. The effect depended on the concentration and the exposure time. An increase in the level of DNA damage in the cells of some donors was noted already at concentrations of 5-12.5 μg/ml. At 25 μg/ml, a statistically significant increase in the «% DNA in the tail comet» parameter was found in lymphocyte of 47 out of 48 donors.
About the Authors
O. V. Egorova
Federal Scientific Center of Hygiene named after F.F. Erisman of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Russian Federation
Russian Federation
2, Semashko st., Mytishchi, 141014, Russian Federation
N. A. Ilyushina
Federal Scientific Center of Hygiene named after F.F. Erisman of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Russian Federation
Russian Federation
2, Semashko st., Mytishchi, 141014, Russian Federation
N. S. Averyanova
Federal Scientific Center of Hygiene named after F.F. Erisman of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Russian Federation
Russian Federation
2, Semashko st., Mytishchi, 141014, Russian Federation
O. V. Gorenskaya
Federal Scientific Center of Hygiene named after F.F. Erisman of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Russian Federation
Russian Federation
2, Semashko st., Mytishchi, 141014, Russian Federation
A. P. Kotnova
Federal Scientific Center of Hygiene named after F.F. Erisman of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Russian Federation
Russian Federation
2, Semashko st., Mytishchi, 141014, Russian Federation
Yu. V. Demidova
Federal Scientific Center of Hygiene named after F.F. Erisman of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Russian Federation
Russian Federation
2, Semashko st., Mytishchi, 141014, Russian Federation
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Review
For citations:
Egorova O.V., Ilyushina N.A., Averyanova N.S., Gorenskaya O.V., Kotnova A.P., Demidova Yu.V. Evaluation of the cyto- and genotoxicity of a fungicide from the phthalimide class. Medical Genetics. 2025;24(5):80-81. (In Russ.) https://doi.org/10.25557/2073-7998.2025.05.80-81
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