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Search of natural selection signals in genomic loci associated with the severity of COVID-19 in Caucasian populations
https://doi.org/10.25557/2073-7998.2025.05.63-64
Abstract
A search of natural selection signals was performed in genomic loci associated with the severity of COVID-19 in 10 Caucasian populations. MALDI-TOF mass spectrometry technology was used for multiplex genotyping of 45 SNP markers. When assessing the selective neutrality of the studied genetic markers using the Evens-Watterson test, deviation from neutrality was found for 8 SNPs.
Supporting agencies: The work was partly supported by the state assignment of the Ministry of Education and Science of Russia No. 122020200083-8.
About the Authors
A. V. Bocharova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050, Russian Federation
R. A. Korneeva
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050, Russian Federation
E. A. Trifonova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050, Russian Federation
V. A. Stepanova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050, Russian Federation
References
1. World Health Organization. WHO COVID-19 dashboard. [Electronic resource]. https://data.who.int/dashboards/covid19 (accessed 01.02 2025).
2. Ovsyannikova I.G., Haralambieva I.H., Crooke S.N. et al. The role of host genetics in the immune response to SARS-CoV-2 and COVID-19 susceptibility and severity. Immunol Rev. 2020;296(1):205-219.
3. WAS Catalog [Electronic resource]. URL: https://www.ebi.ac.uk/gwas/. Accessed 02.2025.
Review
For citations:
Bocharova A.V., Korneeva R.A., Trifonova E.A., Stepanova V.A. Search of natural selection signals in genomic loci associated with the severity of COVID-19 in Caucasian populations. Medical Genetics. 2025;24(5):63-64. (In Russ.) https://doi.org/10.25557/2073-7998.2025.05.63-64
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