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Analysis of generic pesticide mutagenicity in assessing their equivalence to original products
https://doi.org/10.25557/2073-7998.2025.04.68-70
Abstract
Algorithm for assessing the generic pesticide equivalence to original products based on the «mutagenicity» criterion, developed taking into account national characteristics in the field of pesticide handling, as well as examples of algorithm testing are described. To increase the sensitivity of the Ames test and overcome the cytotoxicity of substances from the sulfonylureas and triazolopyrimidines classes, new strains of S. typhimurium were obtained and an optimized testing protocol was developed. The data on the assessment of individual sensitivity to the genotoxic effect of pesticides in a model system on human lymphocytes are presented, indicating the need to take into account the sensitivity of cells from different donors when assessing mutagenicity in vitro.
Supporting agencies: The study was conducted as part of a government assignment (registration number 125012700793-3)
About the Authors
N. A. Ilyushina
F.F.Erisman Federal Scientific Center of Hygiene
Russian Federation
Russian Federation
2, Semashko st., Mytischi, 141000
O. V. Egorova
F.F.Erisman Federal Scientific Center of Hygiene
Russian Federation
Russian Federation
2, Semashko st., Mytischi, 141000
Y. V. Revazova
F.F.Erisman Federal Scientific Center of Hygiene
Russian Federation
Russian Federation
2, Semashko st., Mytischi, 141000
References
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Review
For citations:
Ilyushina N.A., Egorova O.V., Revazova Y.V. Analysis of generic pesticide mutagenicity in assessing their equivalence to original products. Medical Genetics. 2025;24(4):68-70. (In Russ.) https://doi.org/10.25557/2073-7998.2025.04.68-70
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