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Effect of the functional polymorphic variant rs6295 of the HTR1A gene on the efficacy and safety of sertraline in patients with mixed anxiety-depressive disorder
https://doi.org/10.25557/2073-7998.2025.04.44-47
Abstract
Background. Pharmacogenetic studies provide an opportunity to identify accurate predictors of individual responses to antidepressants, which potentially allows personalizing treatment for each specific patient.
Aim: to analyze the association of the rs6295 polymorphism of the HTR1A gene with the efficacy and safety of the selective serotonin inhibitor (SSRI) sertraline in patients with mixed anxiety-depressive disorder from the Republic of Bashkortostan.
Methods. The study included 100 patients taking sertraline for 6 weeks. The efficacy of therapy was assessed using the MontgomeryAsberg MADRS scale, the Clinical Global Impression scale CGI, and the side effect assessment scale UKU.
Results. The severity of depressive symptoms according to the scales and the severity of adverse reactions were statistically significantly higher in carriers of the rs6295*G/G genotype.
Conclusions. Polymorphic variants of the HTR1A gene may be predictors of response to SSRIs.
About the Authors
A. I. Gareeva
Institute of Biochemistry and Genetics – Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences (IBG UFRC RAS);
Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia
Russian Federation
Russian Federation
7, Oktyabrya ave., Ufa, 450054,
2/1, building 1, Barrikadnaya st., Moscow, 125993
L. S. Borodina
Republican Narcological Dispensary No. 1 of the Ministry of Health of the Republic of Bashkortostan
Russian Federation
Russian Federation
119, Pushkina st., Ufa, 450057
E. G. Mikhailova
Republican Narcological Dispensary No. 1 of the Ministry of Health of the Republic of Bashkortostan
Russian Federation
Russian Federation
119, Pushkina st., Ufa, 450057
S. А. Pozdnyakov
Moscow Scientific and Practical Center for Narcology of the Moscow City Department of Health
Russian Federation
Russian Federation
37/1, Lyublinskaya st., Moscow, 109390
I. F. Timerbulatov
Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia
Russian Federation
Russian Federation
2/1, building 1, Barrikadnaya st., Moscow, 125993
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Review
For citations:
Gareeva A.I., Borodina L.S., Mikhailova E.G., Pozdnyakov S.А., Timerbulatov I.F. Effect of the functional polymorphic variant rs6295 of the HTR1A gene on the efficacy and safety of sertraline in patients with mixed anxiety-depressive disorder. Medical Genetics. 2025;24(4):44-47. (In Russ.) https://doi.org/10.25557/2073-7998.2025.04.44-47
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