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Association analysis of polymorphisms in IKZF3, HLA-G and VDR genes with allergic diseases
https://doi.org/10.25557/2073-7998.2025.04.40-41
Abstract
Allergic diseases (AD) are common diseases of multifactorial nature. MicroRNAs play an important role in the AD pathogenesis by regulating the expression of inflammation and immune response-related genes and therefore appear to a promising marker of AD. The selection of gene polymorphisms was based on a thorough analysis of more than 6000 miRNA binding sites polymorphisms in genes involved in AD pathogenesis found in the miRNASNP and MIRDB databases. The aim of the study was the association analysis of polymorphisms in microRNA target sites of IKZF3 (rs907091), HLA-G (rs1063320) and VDR (rs739837) genes with upper respiratory tract AD in individuals of different ethnicity. The rs907091*T allele was associated with asthma and asthma with combined allergic rhinitis (AR) in Russians. The rs1063320*CC genotype was associated with asthma with combined AR in Russians, while the rs1063320*GC genotype was associated with asthma in Tatars. The results of the study suggest a definite role of IKZF3 and HLA-G genes in the AD pathogenesis.
Supporting agencies: The work was performed by the task of the MESRF (No 1022040500074-9) using the equipment of RCSC Agidel with «Human Biological Materials Collection» of the IBG UFRC RAS, supported by the Bioresource Collections Programme of FANO of Russia (No 007-030164/2)
About the Authors
A. O. Vlasova
Institute of Biochemistry and Genetics – a separate structural division of the Ufa Federal Research Center of the Russian Academy of Sciences;
Ufa University of Science and Technology;
Bashkir State Medical University of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
71, Pr. Oktyabrya, Ufa, 450054,
32, Zaki Validi st., Ufa, 450076,
3, Lenina st., Ufa, 450008
A. S. Karunas
Institute of Biochemistry and Genetics – a separate structural division of the Ufa Federal Research Center of the Russian Academy of Sciences;
Ufa University of Science and Technology
Russian Federation
Russian Federation
71, Pr. Oktyabrya, Ufa, 450054,
32, Zaki Validi st., Ufa, 450076
O. N. Savelieva
Institute of Biochemistry and Genetics – a separate structural division of the Ufa Federal Research Center of the Russian Academy of Sciences;
Ufa University of Science and Technology
Russian Federation
Russian Federation
71, Pr. Oktyabrya, Ufa, 450054,
32, Zaki Validi st., Ufa, 450076
I. А. Ishmeeva
Ufa University of Science and Technology
Russian Federation
Russian Federation
32, Zaki Validi st., Ufa, 450076,
E. K. Khusnutdinova
Institute of Biochemistry and Genetics – a separate structural division of the Ufa Federal Research Center of the Russian Academy of Sciences;
Ufa University of Science and Technology;
Bashkir State Medical University of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
71, Pr. Oktyabrya, Ufa, 450054,
32, Zaki Validi st., Ufa, 450076,
3, Lenina st., Ufa, 450008
References
1. Demenais F., Margaritte-Jeannin P., Barnes K.C. et al. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018; 50 (1):42-53.
2. Karunas A.S., Fedorova Y.Y., Gimalova G.F. et al. Association of Gasdermin B Gene GSDMB Polymorphisms with Risk of Allergic Diseases. Biochem Genet. 2021;59(6):1527-1543.
Review
For citations:
Vlasova A.O., Karunas A.S., Savelieva O.N., Ishmeeva I.А., Khusnutdinova E.K. Association analysis of polymorphisms in IKZF3, HLA-G and VDR genes with allergic diseases. Medical Genetics. 2025;24(4):40-41. (In Russ.) https://doi.org/10.25557/2073-7998.2025.04.40-41
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