

Methylation landscape of placenta in pregnancy loss
https://doi.org/10.25557/2073-7998.2025.04.35-36
Abstract
DNA methylation is one of the key mechanisms for controlling the individual development program of an organism. Disruption of this program can be associated with lethal effects during embryogenesis. The aim of the study was to analyze genome-wide methylation disorders in the fetal part of the placenta in cases of pregnancy loss. Genome-wide methylation profiles were analyzed from chorionic villi of spontaneous abortions with a normal karyotype (n = 7) and induced abortions (n = 7). Methylation profiles were obtained using reduced representation bisulfite sequencing (RRBS). Differential methylation of these regions is explained by both insufficient demethylation during reprogramming at the cleavage stage and insufficient methylation when establishing tissue-specific methylation patterns in the fetal part of the placenta.
About the Authors
S. A. VasilyevRussian Federation
Stanislav A. Vasilyev
10, Nab. Ushaiki, Tomsk, 634050
D. G. Shevtsov
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050
A. S. Zuev
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050
O. Yu. Vasilyeva
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050
V. V. Demeneva
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050
E. A. Sazhenova
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050
E. N. Tolmacheva
Russian Federation
10, Nab. Ushaiki, Tomsk, 634050
References
1. Guo H., Zhu P., Yan L. et al. The DNA methylation landscape of human early embryos. Nature. 2014; 511: 606–610. https://doi.org/10.1038/nature13544.
Review
For citations:
Vasilyev S.A., Shevtsov D.G., Zuev A.S., Vasilyeva O.Yu., Demeneva V.V., Sazhenova E.A., Tolmacheva E.N. Methylation landscape of placenta in pregnancy loss. Medical Genetics. 2025;24(4):35-36. (In Russ.) https://doi.org/10.25557/2073-7998.2025.04.35-36