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Methylation landscape of placenta in pregnancy loss

https://doi.org/10.25557/2073-7998.2025.04.35-36

Abstract

DNA methylation is one of the key mechanisms for controlling the individual development program of an organism. Disruption of this program can be associated with lethal effects during embryogenesis. The aim of the study was to analyze genome-wide methylation disorders in the fetal part of the placenta in cases of pregnancy loss. Genome-wide methylation profiles were analyzed from chorionic villi of spontaneous abortions with a normal karyotype (n = 7) and induced abortions (n = 7). Methylation profiles were obtained using reduced representation bisulfite sequencing (RRBS). Differential methylation of these regions is explained by both insufficient demethylation during reprogramming at the cleavage stage and insufficient methylation when establishing tissue-specific methylation patterns in the fetal part of the placenta.

About the Authors

S. A. Vasilyev
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation

Stanislav A. Vasilyev

10, Nab. Ushaiki, Tomsk, 634050



D. G. Shevtsov
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation

10, Nab. Ushaiki, Tomsk, 634050



A. S. Zuev
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation

10, Nab. Ushaiki, Tomsk, 634050



O. Yu. Vasilyeva
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation

10, Nab. Ushaiki, Tomsk, 634050



V. V. Demeneva
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation

10, Nab. Ushaiki, Tomsk, 634050



E. A. Sazhenova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation

10, Nab. Ushaiki, Tomsk, 634050



E. N. Tolmacheva
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation

10, Nab. Ushaiki, Tomsk, 634050



References

1. Guo H., Zhu P., Yan L. et al. The DNA methylation landscape of human early embryos. Nature. 2014; 511: 606–610. https://doi.org/10.1038/nature13544.


Review

For citations:


Vasilyev S.A., Shevtsov D.G., Zuev A.S., Vasilyeva O.Yu., Demeneva V.V., Sazhenova E.A., Tolmacheva E.N. Methylation landscape of placenta in pregnancy loss. Medical Genetics. 2025;24(4):35-36. (In Russ.) https://doi.org/10.25557/2073-7998.2025.04.35-36

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ISSN 2073-7998 (Print)