ASSOCIATION OF FOLATE CYCLE AND INTEGRINS GENES POLYMORPHISMS WITH MISCARRIAGE
https://doi.org/10.1234/XXXX-XXXX-2013-1-40-45
Abstract
Polymorphism of the gene MTHFR, MTRR, MTR, ITGB3, ITGA2, FGB, SERPINE1 were stud i ed in women with miscarriage in the first trimester. There was no association of MTHFR and MTRR gene polymorphism with increased risk of miscarriage. The frequency of allele 2756G MTR gene in women with recurrent miscarriages was higher than for the control group (%2=5,3; p=0.02). The frequencies of polymorphisms of integrins, fibrinogen and plasminogen activator inhibitor genes were simi i ar in both groups. The increased risk of developi ng complications duri ng pregnancy was estabi ished for women with polymorphic variants of genes MTRR, MTR and SERPINE1 (OR=2,3; p=0,013). The presence of polymorphisms of three genes simultaneously (MTRR, MTR and ITGB3)was signifi -cantly higher among women were miscarriage (Or=5,9; p=0.003).
About the Authors
E. V. Mashkina
Research Institute of Biology of Southern Federal University
Russian Federation
344090, Rostov-on-Don, av. Stachki, 194/1
Russian Federation
344090, Rostov-on-Don, av. Stachki, 194/1
K. A. Kovalenko
Research Institute of Biology of Southern Federal University
Russian Federation
344090, Rostov-on-Don, av. Stachki, 194/1
Russian Federation
344090, Rostov-on-Don, av. Stachki, 194/1
L. V. Gutnikova
Research Institute of Biology of Southern Federal University
Russian Federation
344090, Rostov-on-Don, av. Stachki, 194/1
Russian Federation
344090, Rostov-on-Don, av. Stachki, 194/1
E. G. Derevyanchuk
Research Institute of Biology of Southern Federal University
Russian Federation
344090, Rostov-on-Don, av. Stachki, 194/1
Russian Federation
344090, Rostov-on-Don, av. Stachki, 194/1
T. P. Shkurat
Research Institute of Biology of Southern Federal University
Russian Federation
344090, Rostov-on-Don, av. Stachki, 194/1
Russian Federation
344090, Rostov-on-Don, av. Stachki, 194/1
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Review
For citations:
Mashkina E.V., Kovalenko K.A., Gutnikova L.V., Derevyanchuk E.G., Shkurat T.P. ASSOCIATION OF FOLATE CYCLE AND INTEGRINS GENES POLYMORPHISMS WITH MISCARRIAGE. Medical Genetics. 2013;12(1):40-45. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2013-1-40-45
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