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Association of IL 6 rs1800795 genetic variation with the susceptibility and severity of COVID-19: A meta-analysis
https://doi.org/10.25557/2073-7998.2024.05.22-30
Abstract
Coronavirus disease 2019 (COVID-19) is a highly contagious infectious disease, which caused a global pandemic. The differences of symptoms among COVID-19 patients made it important to search for the factors that may play a significant role in its pathogenesis. The aim of the current study was to investigate the association of interleukin 6 (IL-6) genetic variation rs1800795 with both susceptibility and severity of COVID-19, by performing a meta-analysis of the available data in the literature. Several databases were searched using specific keywords, and a total of 12 full-text articles were included in the analysis. No association was found with the COVID-19 susceptibility. However, a significant association was found between the studied polymorphism and the COVID-19 severity in the recessive model of inheritance (OR =2.11, 95% CI [1.12, 3.98], p=0.02). To our knowledge, this meta-analysis is the first to study the association of IL6 rs1800795 with both susceptibility and severity of COVID-19, and its results reflect the current published data, and may serve as a guide for further research.
About the Authors
E. S. Ivanova
Southern Federal University
Russian Federation
Russian Federation
105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006
M. A. Eid
Southern Federal University
Russian Federation
Russian Federation
105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006
T. P. Shkurat
Southern Federal University
Russian Federation
Russian Federation
105/42, Bolshaya Sadovaya st., Rostov-on-Don, 344006
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Review
For citations:
Ivanova E.S., Eid M.A., Shkurat T.P. Association of IL 6 rs1800795 genetic variation with the susceptibility and severity of COVID-19: A meta-analysis. Medical Genetics. 2024;23(5):22-30. https://doi.org/10.25557/2073-7998.2024.05.22-30
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