The role of the ACE gene in the development of severe form of COVID-19 in pregnant women
https://doi.org/10.25557/2073-7998.2024.02.27-33
Abstract
The use of genetic polymorphisms in determining the pathogenesis of the disease increases the effectiveness of early diagnosis and preventive measures of severe form of coronavirus. COVID-19 and its complications with pneumonia are a potential risk factor for pregnant women and can have negative consequences for both the mother and the fetus. Currently, special attention is paid to the study of the role of genetic factors in the outbreak of the coronavirus. The aim of the study: to determine the role of the ACE gene Alu-element I/D polymorphism in the pathogenesis of COVID-19. According to the results of molecular-genetic examination and statistical analysis, alleles and genotypes of ACE gene I/D polymorphism in pregnant women infected with coronavirus did not have significant differences compared to the control group (p=0.05). Conclusion: It is impossible to use this locus of the ACE gene to predict COVID-19 and its complications.
Keywords
About the Authors
M. O. Komilova
Andijan State Medical Institute
Uzbekistan
Uzbekistan
Andijan
K. T. Boboev
Republican Specialized Scientific and Practical Medical Center of Hematology
Uzbekistan
Uzbekistan
Tashkent
Sh. A. Zufarova
Republican Population Reproductive Health Center
Uzbekistan
Uzbekistan
Tashkent
A. S. Yuldasheva
Andijan State Medical Institute
Uzbekistan
Uzbekistan
Andijan
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Review
For citations:
Komilova M.O., Boboev K.T., Zufarova Sh.A., Yuldasheva A.S. The role of the ACE gene in the development of severe form of COVID-19 in pregnant women. Medical Genetics. 2024;23(2):27-33. (In Russ.) https://doi.org/10.25557/2073-7998.2024.02.27-33
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