Sperm mitochondrial DNA copy number and male fertility
https://doi.org/10.25557/2073-7998.2023.12.45-51
Abstract
Currently, the study of mitochondrial genome in male and female gametes is one of the actively investigated topics in reproductive genetics. A number of authors argue that there is an association between mtDNA copy number, quality of gametes, and fertility potential. Male fertility depends on a large extent on seminal fluid parameters, in particular on the quantity and quality of spermatozoa, which are influenced by many genetic and non-genetic factors. Some of the genetic factors of decreased sperm motility are mitochondrial dysfunction, mitochondrial DNA (mtDNA) abnormalities in male germ cells. This article presents a brief review of the results of studies related to the mitochondrial DNA content in normal sperm parameters and various forms of pathozoospermia.
About the Authors
S. Sh. Khayat
Research Centre for Medical Genetics
Russian Federation
Russian Federation
1, Moskvorechie st., Moscow, 115478
L. F. Kurilo
Research Centre for Medical Genetics
Russian Federation
Russian Federation
1, Moskvorechie st., Moscow, 115478
V. B. Chernykh
Research Centre for Medical Genetics
Russian Federation
Russian Federation
1, Moskvorechie st., Moscow, 115478
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For citations:
Khayat S.Sh., Kurilo L.F., Chernykh V.B. Sperm mitochondrial DNA copy number and male fertility. Medical Genetics. 2023;22(12):45-51. (In Russ.) https://doi.org/10.25557/2073-7998.2023.12.45-51
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