Association of allelic variants of the STOX1 gene with preeclampsia in Russian population samples
https://doi.org/10.25557/2073-7998.2023.11.40-46
Abstract
Preeclampsia (PE) is a severe obstetric pathology that affects up to 8% of all pregnancies per year. By now numerous genetic studies have been conducted using both candidate and genome-wide approaches to reveal the genetic basis of PE. Therefore, a number of promising candidate genes for PE, including the STOX1 locus, were identified. In this article, the role of heritable variation of the STOX1 gene in the formation of predisposition to PE in various ethnic groups of Russia was analyzed. The associations of genotypes of the STOX1 locus with PE that we found were characterized by population specificity. Genotypes of polymorphic markers rs4746796 and rs7095976 with risk effect were identified in Russians. The protective genotype of the rs1694505 allele variant was revealed in the Yakut ethnicity.
Supporting agencies: The work was carried out under the state order for fundamental scientific research No. 122020200083-8 “Population genomics and human transcriptomics: analysis of the formation of the genetic architecture of diseases in the context of evolutionary medicine.”
About the Authors
E. A. Trifonova
Tomsk National Research Medical Center of the Russian Academy of Sciences, Research Institute of Medical Genetics
Russian Federation
Russian Federation
10, Naberejnaya Ushaiki, Tomsk, 634050
A. A. Babovskaya
Tomsk National Research Medical Center of the Russian Academy of Sciences, Research Institute of Medical Genetics
Russian Federation
Russian Federation
10, Naberejnaya Ushaiki, Tomsk, 634050
M. M. Gavrilenko
Tomsk National Research Medical Center of the Russian Academy of Sciences, Research Institute of Medical Genetics
Russian Federation
Russian Federation
10, Naberejnaya Ushaiki, Tomsk, 634050
V. A. Stepanov
Tomsk National Research Medical Center of the Russian Academy of Sciences, Research Institute of Medical Genetics
Russian Federation
Russian Federation
10, Naberejnaya Ushaiki, Tomsk, 634050
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Review
For citations:
Trifonova E.A., Babovskaya A.A., Gavrilenko M.M., Stepanov V.A. Association of allelic variants of the STOX1 gene with preeclampsia in Russian population samples. Medical Genetics. 2023;22(11):40-46. (In Russ.) https://doi.org/10.25557/2073-7998.2023.11.40-46
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