Genesis of multiple tumors in a patient with a primary endometral adenocarcinoma

The number of cases with the description of primary multiple tumors is growing, however, reports of synchronous-metachronous neoplasms are extremely rare. Moreover, there is practically no genetic analysis of such tumors and possible ways of their progression in the literature. The purpose of this study was to establish the independence of the origin of multiple tumors in a patient with Lynch syndrome. A retrospective analysis of the material included both the study of the morphological features of tumors and the detection of mutational damage in the studied genes by whole exome sequencing of DNA isolated from available paraffin blocks. The combination of histological types and established mutational profiles of neoplasms confirms their independent origin. Thus, a new case of primary multiple tumors is presented and possible ways of their formation with the participation of congenital disorders of the DNA mismatch repair system are suggested.

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