Role of polymorphic variants of NO synthase and arginase genes in child bronchial asthma
Abstract
The results of associations study of NO-synthase and arginase genes and asthma of children living in Moscow are presented. 207 children and adolescents are examined (107 with asthma and 100 healthy controls). Analysis of polymorphism of NOS1 , NOS2 , NOS3 , ARG1, ARG2 genes was carried out. The association of asthma and polymorphic variants CCTTTn of NOS2A gene was established in the total group and in the groups of boys and girls. Gender differences were revealed. Significant gene-gene interactions of polymorphic loci of the studied genes NO-synthase and arginase in the asthma development were determined. Associations of combinations of NOS2А (CCTTT)n*SL x ARG2 (rs3742879)*AA genotypes with the increased risk of asthma development in girls has been revealed.
About the Authors
B. T. Batozhargalova
Academician Yu. E. Veltishchev Research Clinical Institute of Pediatrics; Morozov City Children’s Clinical Hospital
Russian Federation
Russian Federation
Y. L. Mizernitski
Academician Yu. E. Veltishchev Research Clinical Institute of Pediatrics
Russian Federation
Russian Federation
S. E. Diakova
Academician Yu. E. Veltishchev Research Clinical Institute of Pediatrics
Russian Federation
Russian Federation
N. V. Petrova
Science Research Centre for Medical Genetics
Russian Federation
Russian Federation
R. A. Zinchenko
Academician Yu. E. Veltishchev Research Clinical Institute of Pediatrics; Science Research Centre for Medical Genetics
Russian Federation
Russian Federation
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Review
For citations:
Batozhargalova B.T., Mizernitski Y.L., Diakova S.E., Petrova N.V., Zinchenko R.A. Role of polymorphic variants of NO synthase and arginase genes in child bronchial asthma. Medical Genetics. 2017;16(2):40-48. (In Russ.)
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