The analysis of relationship between the A/G (rs1801310) polymorphism of the GSS gene and the development of uterine myoma: a pilot study
Abstract
The aim of our study was to investigate the relationship between GSS A/G (rs1801310) gene polymorphism and the development of UM in the population of Central Russia. 336 patients with UM and 205 healthy women were enrolled in this study. Genotyping of A/G gene polymorphism was performed through TaqMan assay. Allele G was associated with increased risk of UM development (OR = 1,30; 95% Cl = 1,01-1,67; p = 0,04). Meanwhile we observed the protective effect of AA genotype on the development of UM (OR = 0,60; 95% Cl = 0,39-0,94; p = 0,03).
About the Authors
O. K. Kudryavtseva
Kursk Regional Hospital
Russian Federation
Russian Federation
E. M. Barysheva
Kursk State Medical University
Russian Federation
Russian Federation
M. V. Sorokina
Kursk City hospital № 2
Russian Federation
Russian Federation
O. B. Polshvedkina
Kursk State Medical University
Russian Federation
Russian Federation
N. V. Ivanova
Kursk State Medical University
Russian Federation
Russian Federation
A. V. Polonikov
Kursk State Medical University
Russian Federation
Russian Federation
O. Yu. Bushueva
Kursk State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Kudryavtseva O.K., Barysheva E.M., Sorokina M.V., Polshvedkina O.B., Ivanova N.V., Polonikov A.V., Bushueva O.Yu. The analysis of relationship between the A/G (rs1801310) polymorphism of the GSS gene and the development of uterine myoma: a pilot study. Medical Genetics. 2017;16(2):37-39. (In Russ.)
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