GC-rich fragments in circulating free DNA accelerate replicative aging in cultured human skin fibroblasts
https://doi.org/10.25557/2073-7998.2022.12.16-17
Abstract
Purpose of the study: to determine the impact of rDNA fragments in the culture medium on the rate of replicative cell aging. We found that GC-rich fragments in extracellular DNA accelerate the replicative aging of cultured human skin fibroblasts and increase the level of reactive oxygen species in cells.
About the Authors
E. S. Ershova
Research Centre for Medical Genetics
Russian Federation
Russian Federation
L. V. Kameneva
Research Centre for Medical Genetics
Russian Federation
Russian Federation
N. N. Veiko
Research Centre for Medical Genetics
Russian Federation
Russian Federation
S. V. Kostyuk
Research Centre for Medical Genetics
Russian Federation
Russian Federation
References
1. Kustanovich A., Schwartz R., Peretz T., Grinshpun A. Life and death of circulating cell-free DNA. Cancer Biol Ther. 2019;20(8):1057-1067. doi: 10.1080/15384047.2019.1598759
2. Ershova E.S., Konkova M.S., Malinovskaya E.M., Kutsev S.I., Veiko N.N., Kostyuk S.V. Noncanonical functions of the human ribosomal repeat Russian Journal of Genetics. 2020;56(1):30-40
3. Wang Y., Wang L., Wen X., Hao D., Zhang N., He G., Jiang X. NF-κB signaling in skin aging. Mech Ageing Dev. 2019; 184:111160. doi: 10.1016/j.mad.2019.111160
4. Umriukhin P.E., Ershova E.S., Filev A.D., et al. The Psychoemotional Stress-Induced Changes in the Abundance of SatIII (1q12) and Telomere Repeats, but Not Ribosomal DNA, in Human Leukocytes. Genes (Basel). 2022;13(2):343. doi: 10.3390/genes13020343
Review
For citations:
Ershova E.S., Kameneva L.V., Veiko N.N., Kostyuk S.V. GC-rich fragments in circulating free DNA accelerate replicative aging in cultured human skin fibroblasts. Medical Genetics. 2022;21(12):16-17. (In Russ.) https://doi.org/10.25557/2073-7998.2022.12.16-17
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