Сhronic exposure effect on the telomere regions of the chromosomes of the human peripheral blood lymphocytes
https://doi.org/10.25557/2073-7998.2022.11.40-43
Abstract
The aim of the research was to study the influence of the chronic radiation exposure and non-radiation factors on the length of the telomere regions of the human chromosomes. The object of the study: peripheral blood T-cells of the chronically exposed residents of the Techa riverside settlements. The length of the telomere regions of the 1st, 2nd, 3rd, 13th, 14th, 15th,19th, 20th, 21st and 22nd pair of chromosomes has been estimated using the method of fluorescent staining (Q-FISH) of the telomeres coupled with DAPI counterstaining. The findings of the study demonstrate that the length of the telomeres in one cell varies greatly; the size of the telomere region does not depend on the length of a chromosome or a chromosome arm where it is located. The value of the telomere length in men is statistically significantly high as compared to women. In the comparison group, the length of the telomere regions in many chromosomes statistically significantly exceeds that in the exposed group.
About the Author
Ya. V. Krivoshchapova
Ural Research Center for Radiation Medicine FMBA
Russian Federation
Russian Federation
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Review
For citations:
Krivoshchapova Ya.V. Сhronic exposure effect on the telomere regions of the chromosomes of the human peripheral blood lymphocytes. Medical Genetics. 2022;21(11):40-43. (In Russ.) https://doi.org/10.25557/2073-7998.2022.11.40-43
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