Study of the bacterial microbiome of sputum of patients with lung cancer and its association with chromosome damage in peripheral blood lymphocytes
https://doi.org/10.25557/2073-7998.2022.11.16-18
Abstract
The microbiome of the respiratory tract can have a significant impact on the development of a number of diseases of the human respiratory system. In addition to dysbiotic changes in the composition of the microbiome of patients, it was noted that many bacteria have a genotoxic potential and are able to directly or indirectly damage the genome in the cells of the host organism. The aim of the study was to study the relationship between the composition of the sputum microbiome and the level of chromosome damage in the blood leukocytes of patients with lung cancer (LC). The taxonomic composition of the sputum bacterial microbiome, as well as the basic frequencies of chromosomal aberrations (CA) and micronuclei (MN) in blood lymphocytes of 66 men diagnosed with LC and 62 healthy donors were studied. The results of sequencing showed that the microbiome of LC patients has signs of dysbiosis with a significant increase in the content of bacteria of the genera Streptococcus, Bacillus, Gemella and Haemophilus. In patients with LC, a direct relationship was found between the frequency of aberrant metaphases in lymphocytes and the percentage of representatives of the genus Bacteroides in sputum.
About the Authors
E. D. Baranova
Kemerovo State University
Russian Federation
Russian Federation
V. G. Druzhinin
Kemerovo State University
Russian Federation
Russian Federation
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Review
For citations:
Baranova E.D., Druzhinin V.G. Study of the bacterial microbiome of sputum of patients with lung cancer and its association with chromosome damage in peripheral blood lymphocytes. Medical Genetics. 2022;21(11):16-18. (In Russ.) https://doi.org/10.25557/2073-7998.2022.11.16-18
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