Chromosomal aberrations in blood cells of lung cancer patients in miners of the Kemerovo region
https://doi.org/10.25557/2073-7998.2022.11.12-15
Abstract
Mining has a direct impact on the environment and on the health of miners and is considered one of the most hazardous occupations worldwide. The aim of this study was the analysis of chromosomal aberrations (CAs) in lung cancer patients and healthy donors resident in the same territory. Statistical analysis were performed using nonparametric statistics (Mann-Whitney U Test for paired comparison of quantitative characteristics), logistic regression. It was determined that the CAs frequency (both chromatid- and chromosome-type aberrations) was significantly increased in lung cancer patients compared to control group.
About the Authors
M. L. Bakanova
Federal Research Centre of Coal and Coal-Chemistry of Siberian Branch of the SD RAS; Kemerovo State Medical University; Kemerovo State University
Russian Federation
Russian Federation
V. I. Minina
Federal Research Centre of Coal and Coal-Chemistry of Siberian Branch of the SD RAS; Kemerovo State University
Russian Federation
Russian Federation
A. A. Timofeeva
Federal Research Centre of Coal and Coal-Chemistry of Siberian Branch of the SD RAS
Russian Federation
Russian Federation
Ya. A. Savchenko
Federal Research Centre of Coal and Coal-Chemistry of Siberian Branch of the SD RAS; Kemerovo State University
Russian Federation
Russian Federation
E. A. Astaf´eva
Federal Research Centre of Coal and Coal-Chemistry of Siberian Branch of the SD RAS; Kemerovo State University
Russian Federation
Russian Federation
A. N. Glushkov
Federal Research Centre of Coal and Coal-Chemistry of Siberian Branch of the SD RAS
Russian Federation
Russian Federation
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Review
For citations:
Bakanova M.L., Minina V.I., Timofeeva A.A., Savchenko Ya.A., Astaf´eva E.A., Glushkov A.N. Chromosomal aberrations in blood cells of lung cancer patients in miners of the Kemerovo region. Medical Genetics. 2022;21(11):12-15. (In Russ.) https://doi.org/10.25557/2073-7998.2022.11.12-15
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