Association of Adiponectin and Leptin Genetic Polymorphisms with Clinical Manifestations of Metabolic Syndrome

Abdominal obesity connecting with polygenic hereditary defects is considered the initial event in metabolic syndrome (MS) development. The purpose of study was to analyse the frequency of adiponectin (ADIPOQ) and leptin (LEP) gene polymorphisms in patients with MS, and the association of MS’s symptoms with named genes’ polymorphism. DNA was isolated from the whole blood of 207 patients with MS and 100 healthy individuals (control group). Gene polymorphisms were determined by real-time polymerase chain reaction. The association of the GG genotype of -2548 A/G polymorphism of the LEP gene (rs7799039) with the risk of high blood pressure in patients with MS, and the genotype of GG polymorphism + 45 T/G of the ADIPOQ gene (rs2241766) with hyperglycemia as a leading link in the development of MS was established. The association of the allele G of polymorphism +45 T/G (rs2241766) of the ADIPOQ gene with the risk of metabolic syndrome was established (OR (95% CI) =5,6 (2,4-13,0)), as well as the association of the TG and GG genotypes of this genetic variant (OR (95% CI)=3.81 (1.79-8.09) and OR (95% CI)=10.0 (2.25-44.7).

polymorphism, adiponectin, leptin, metabolic syndrome

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