Variability of mitochondrial genome of the type 1 diabetes

Abstract

Preeclampsia (PE) occurs in 2-8% of pregnancies and is one of the most important causes of maternal and perinatal morbidity and mortality in the world. Numerous studies have demonstrated the key role of impaired placentation processes associated with pathological trophoblast invasion and reduced remodeling of myometrial spiral arteries in the development of PE. The molecular mechanisms and genetic factors behind this observation are still unclear. On the example of PE, we tested a systematic approach to the search for promising biomarkers of gestational complications, which is based on a combination of genomic, transcriptomic, and bioinformatic methods. This approach has demonstrated its effectiveness and made it possible to discover new genetic markers of PE, to reveal the significant role of regulatory regions of the human genome in susceptibility to this disease.