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Associations of SLC1A2 gene polymorphisms with the type of schizophrenia
https://doi.org/10.25557/2073-7998.2022.08.27-30
Abstract
Currently, the type of course of schizophrenia is a key feature in the classification of the disease. In this work, associations of polymorphic variants of the SLC1A2 gene with this trait were studied. Glutamate is the main excitatory neurotransmitter in the central nervous system. The SLC1A2 gene encodes EAAT2, one of the excitatory amino acid transporters (EAATs) that potentially influence glutamatergic neurotransmission by removing excess glutamate from the synaptic cleft. The study group included 655 patients with schizophrenia, 2 subgroups were identified: a subgroup of 398 patients with a continuous course of schizophrenia and a subgroup of 257 patients with episodic schizophrenia. Genotyping of 11 polymorphic variants of the SLC1A2 gene was carried out. It was found that the CT genotype and the C allele rs1042113 SLC1A2, as well as the CT genotype rs12294045 SLC1A2, were associated with the continuous course of schizophrenia. Thus, the present study showed the involvement of the SLC1A2 gene in determining the type of course of schizophrenia.
About the Authors
E. G. Poltavskaya
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
E. G. Kornetova
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
V. I. Gerasimova
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
A. V. Bocharova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
S. A. Ivanova
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
O. Yu. Fedorenko
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Poltavskaya E.G., Kornetova E.G., Gerasimova V.I., Bocharova A.V., Ivanova S.A., Fedorenko O.Yu. Associations of SLC1A2 gene polymorphisms with the type of schizophrenia. Medical Genetics. 2022;21(8):27-30. (In Russ.) https://doi.org/10.25557/2073-7998.2022.08.27-30
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