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Comparative characteristics of cytokine gene polymorphism in children with different variants of bronchial asthma
https://doi.org/10.25557/2073-7998.2022.08.13-16
Abstract
Asthma is a complex,multifactorial and heterogenic inflammatory disease of the airways, associated withan imbalance between pro-inflammatory and anti-inflammatory cytokines and characterized by genetic determinism. Most patients with severe asthma are classified as T2-endotypeand have eosinophilic inflammation in the mucosa of the lower respiratory tract. The aim of the study was to analyze the distribution of genotypes IL4 rs2243250, IL5 rs2069812, IL13 rs1800925 in children with different phenotypes of bronchial asthma. Genotyping of polymorphisms was performedusing RT-PCR. The frequency of the TT genotype and the T allele rs1800925 IL13 has been shown to be significantly higher in patients with the eosinophilic asthma phenotype compared with a control group of healthy children (p<0,05).
About the Authors
M. A. Malinchik
Research Institute of Medical Problems of the North, Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences
Russian Federation
Russian Federation
M. V. Smolnikova
Research Institute of Medical Problems of the North, Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Malinchik M.A., Smolnikova M.V. Comparative characteristics of cytokine gene polymorphism in children with different variants of bronchial asthma. Medical Genetics. 2022;21(8):13-16. (In Russ.) https://doi.org/10.25557/2073-7998.2022.08.13-16
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