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Influence of a genetic variant of schizophrenia risk at the ZNF804A locus and the presence of alcoholism in the parental family on the deficiency of emotion recognition in schizophrenia
https://doi.org/10.25557/2073-7998.2022.08.9-12
Abstract
Background. In recent decades, special attention in the study of schizophrenia has been paid to the features of emotion recognition and the influence of both genetic and environmental factors on the development of the individual and the risk of developing mental illness. There is an assumption that disorders of emotion recognition are one of the endophenotypes of the disease. The important role of the violation of social cognitions, and in particular the recognition of emotions, in the social adaptation of patients with schizophrenia has been established. Establishing the role of genetic and environmental risk factors for schizophrenia in these disorders is an important step towards the formation of therapeutic approaches to their correction. Aim - to assess the contribution of the rs1344706 polymorphism of the ZNF804A gene and an unfavorable environment in childhood (the presence of alcoholism in the parental family) to the recognition of emotions in patients. Methods. The sample consisted of 854 patients divided into two groups: with alcoholism in the parental family and without it. To assess the recognition of mimic expression of emotions, photographs of six basic and three social emotions were used. Genotyping was performed by the HRM method. Results. An interaction effect between the genetic variant ZNF804A (rs1344706) and alcohol abuse by one of the proband’s parents on impairment of emotion recognition was found (p=0.02). Patients with the AA genotype were worse at recognizing emotions than those with the CC genotype. Conclusion. The results suggest an important role for the interaction of neurodevelopmentally associated schizophrenia risk genes and early environmental stressors in social cognition anomalies in schizophrenia.
About the Authors
T. V. Lezheiko
Mental Health Research Center
Russian Federation
Russian Federation
M. V. Alfimova
Mental Health Research Center
Russian Federation
Russian Federation
V. E. Golimbet
Mental Health Research Center
Russian Federation
Russian Federation
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For citations:
Lezheiko T.V., Alfimova M.V., Golimbet V.E. Influence of a genetic variant of schizophrenia risk at the ZNF804A locus and the presence of alcoholism in the parental family on the deficiency of emotion recognition in schizophrenia. Medical Genetics. 2022;21(8):9-12. (In Russ.) https://doi.org/10.25557/2073-7998.2022.08.9-12
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