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Damage to cellular DNA is associated with a decrease in the number of the satellite III repeat copies (1q12) in the blood cells DNA of patients with schizophrenia
https://doi.org/10.25557/2073-7998.2022.07.50-51
Abstract
Schizophrenia is a multifactorial disease resulting from genetic disorders and unfavorable conditions of embryonic development and later life. The study revealed a pronounced negative correlation between markers of DNA damage in blood lymphocytes (oxidation marker 8-oxodG, double-strand break marker γH2AX) and the repeat content - satellite III subfraction (located in pericentromeric heterochromatin 1q12) in a sample of patients with schizophrenia in the acute stage (N = 97). The low content of the f-SatIII repeat in the DNA of leukocytes of patients can be considered as a potential marker of the level of both chronic oxidative stress and DNA damage in schizophrenia.
About the Authors
E. M. Jestkova
P.B. Gannushkin Clinical Psychiatric Hospital No 4
Russian Federation
Russian Federation
E. S. Ershova
Research Centre for Medical Genetics
Russian Federation
Russian Federation
N. V. Zakharova
N. A. Alexeev Clinical Psychiatric Hospital No 1
Russian Federation
Russian Federation
L. V. Kameneva
Research Centre for Medical Genetics
Russian Federation
Russian Federation
N. N. Veiko
Research Centre for Medical Genetics
Russian Federation
Russian Federation
S. V. Kostyuk
Research Centre for Medical Genetics
Russian Federation
Russian Federation
References
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2. Ershova E.S., Malinovskaya E.M., Golimbet V.E., Lezheiko T.V., Zakharova N.V., Shmarina G.V., Veiko R.V., Umriukhin P.E., Kostyuk G.P., Kutsev S.I., Izhevskaya V.L., Veiko N.N., Kostyuk S.V. Copy number variations of satellite III (1q12) and ribosomal repeats in health and schizophrenia. Schizophr Res. 2020 Sep;223:199-212. doi: 10.1016/j.schres.2020.07.022.
Review
For citations:
Jestkova E.M., Ershova E.S., Zakharova N.V., Kameneva L.V., Veiko N.N., Kostyuk S.V. Damage to cellular DNA is associated with a decrease in the number of the satellite III repeat copies (1q12) in the blood cells DNA of patients with schizophrenia. Medical Genetics. 2022;21(7):50-51. (In Russ.) https://doi.org/10.25557/2073-7998.2022.07.50-51
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