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Gene-Gene Interactions study of diseases with decline human cognitive functions
https://doi.org/10.25557/2073-7998.2022.07.24-29
Abstract
An analysis of intergenic interactions in relation to the risk of developing schizophrenia (in the population of Russians and Kazakhs) and Alzheimer’s disease (in the population of Russians) was carried out using the Multifactor Dimensionality Reduction (MDR) method. 16 combinations of genotypes associated with a high or low risk of developing schizophrenia or Alzheimer’s disease were identified: 7 combinations of genotypes of the VRK2, ZNF804A, ZFP67P genes for schizophrenia in the Russian population, 7 combinations of genotypes of the KCNB2, ZFP64P, NRIP1 genes for schizophrenia in the Kazakh population, two combinations of genotypes APOE and CSMD1 genes for Alzheimer’s disease in the Russian population. The results of the work indicate that the cumulative contribution of risk gene variants plays an important role in the development of pathology in diseases with cognitive impairment.
About the Authors
A. V. Bocharova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
A. V. Marusin
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
O. A. Makeeva
Nebbiolo Centre for Clinical Trials
Russian Federation
Russian Federation
I. A. Zhukova
Nebbiolo Centre for Clinical Trials; Siberian State Medical University
Russian Federation
Russian Federation
N. G. Zhukova
Nebbiolo Centre for Clinical Trials; Siberian State Medical University
Russian Federation
Russian Federation
O. Yu. Fedorenko
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
S. A. Ivanova
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
A. V. Semke
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
V. A. Stepanov
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Bocharova A.V., Marusin A.V., Makeeva O.A., Zhukova I.A., Zhukova N.G., Fedorenko O.Yu., Ivanova S.A., Semke A.V., Stepanov V.A. Gene-Gene Interactions study of diseases with decline human cognitive functions. Medical Genetics. 2022;21(7):24-29. (In Russ.) https://doi.org/10.25557/2073-7998.2022.07.24-29
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