Association analysis of miRNA-146a SNPs rs57095329 and rs2910164 with the efficacy of immune checkpoint inhibitors of clear cell renal cell carcinoma therapy

Immune checkpoint inhibitors (ICIs) have made a revolutionary breakthrough in the cancer treatment, particularly clear cell renal cell carcinoma (ccRCC), but a substantial proportion of patients show therapy resistance. The reasons for the different treatment outcomes are still unclear. MicroRNAs involved in the regulation of many cancer and immune cell pathways are actively studied as potential biomarkers. Some microRNAs are factors determining the ICI efficacy. We analyzed the associations of rs57095329 and rs2910164 polymorphic variants of microRNA-146a with the risk of complications and resistance during ICI treatment in 86 patients with metastatic ccRCC. Association analysis of rs2910164 showed that CC genotype and the C allele had a higher risk of developing severe immune-mediated reactions when treated with ICIs.

immune checkpoint inhibitors, SNP, drug resistance, renal cell carcinoma, miRNA

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