The expression of microRNA and genes as candidates for the gastric cancer metastasis markers
https://doi.org/10.25557/2073-7998.2021.11.18-24
Abstract
Gastric cancer (GC) is one of the significant causes of mortality from cancer. An unfavorable forecast for GC is largely associated with tumor metastasis. Expression of genes and microRNAs can be a source of biomarkers that signal the increased risk of tumor metastasis. The detection of genes associated with tumor metastasis, and the creation of a candidate prognostic panel of microRNAs and genes is very relevant. We investigated the expression of MIR-34A and MIR -335 microRNA and FGFR2, VEGFR1 and NRP1 genes with disseminated gastric cancer in comparison with non-metastatic GC tumors. Association is characterized with the development of remote metastasis, indicating their quality as candidates for markers. Panels are formed, including genes, and microRNAs - candidates for prognostic markers. A comparative analysis of the panels allowed to be characterized as the most efficient panel, including MIR335/VEGFR1/FGFR2, which demonstrates the best indicators as a candidate for the metastasis prediction panel, especially the value of the ratio of the chance of OR = 143 and RR = 7.1.
About the Authors
F. M. Kipkeeva
Research Centre for Medical Genetics
Russian Federation
Russian Federation
T. A. Muzaffarova
Research Centre for Medical Genetics
Russian Federation
Russian Federation
M. P. Nikulin
N.N. Blokhin National Medical Research Center of Oncology оf the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
D. Zh. Mansorovov
Research Centre for Medical Genetics
Russian Federation
Russian Federation
P. V. Apanovich
Research Centre for Medical Genetics
Russian Federation
Russian Federation
O. A. Malikhova
N.N. Blokhin National Medical Research Center of Oncology оf the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
A. V. Karpukhin
Research Centre for Medical Genetics
Russian Federation
Russian Federation
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Review
For citations:
Kipkeeva F.M., Muzaffarova T.A., Nikulin M.P., Mansorovov D.Zh., Apanovich P.V., Malikhova O.A., Karpukhin A.V. The expression of microRNA and genes as candidates for the gastric cancer metastasis markers. Medical Genetics. 2021;20(11):18-24. (In Russ.) https://doi.org/10.25557/2073-7998.2021.11.18-24
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