The role of alcohol metabolism enzymes in chronic alcoholic pancreatitis (review)
https://doi.org/10.25557/2073-7998.2021.04.3-8
Abstract
Alcohol metabolism is a decisive biological factor that significantly affects alcohol abuse, the development of alcoholism and alcohol damage to organs. The main pathway of ethanol metabolism is the alcohol dehydrogenase pathway to acetaldehyde, which passes into the mitochondria and is oxidized to acetic acid. 80-90% of all ethanol passes through this path. Alcohol oxidase (cytochrome P450), also called microsomal ethanol oxidation system (MEOS/CYP2E1), is responsible for the oxidation of 10-20% of ethanol. The main alcohol metabolizing enzymes exhibit genetic polymorphism and ethnic variation. This review presents recent advances in understanding the functional polymorphisms of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) and their metabolic, physiological, and clinical correlations.
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Review
For citations:
Aliyeva G.R. The role of alcohol metabolism enzymes in chronic alcoholic pancreatitis (review). Medical Genetics. 2021;20(4):3-8. (In Russ.) https://doi.org/10.25557/2073-7998.2021.04.3-8
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