Contribution of risk factors in the development of chronic pancreatitis in carriers of rs213950 CFTR
https://doi.org/10.25557/2073-7998.2021.02.21-26
Abstract
Chronic pancreatitis is the multifactorial disease, genetic and environmental factors play a role in the development of it. The aim was to determine the contribution of rs213950 CFTR gene to the risk of chronic pancreatitis (CP). DNA samples obtained from 302 unrelated patients with chronic pancreatitis and 465 unrelated individuals without gastrointestinal diseases. Genotyping was performed using the PCR method with discrimination of alleles using TaqMan probes. The χ2 criterion and the odds ratio (OR) with 95% confidence intervals (CI) were used to assess the associations of alleles and genotypes of genes with the risk of the disease. We found an association of the A allele rs213950 of the CFTR gene with an increased risk of chronic pancreatitis (OR=1,24, CI 95%=1,01-1,53, P=0,04). Also, the risk of CP increased in smokers with the A/G-A/A genotypes (OR=2,07, CI 95%=1,13-3,78, P=0,017D) and with alcohol abuse for more than 10 years in carriers of the A/A genotype (OR=2,23, CI 95%=1,12-4,47, P=0,02R). The frequency and volume of alcohol consumed in carriers of the rs213950 polymorphism of the CFTR gene didn’t reveal statistically significant differences.
About the Authors
T. A. Samgina
Kursk State Medical University
Russian Federation
Russian Federation
D. I. Kolmykov
Kursk State Medical University
Russian Federation
Russian Federation
G. N. Myasnyankina
Kursk State Medical University
Russian Federation
Russian Federation
S. M. Gorbunov
Kursk State Medical University
Russian Federation
Russian Federation
Iu. E. Azarova
Kursk State Medical University
Russian Federation
Russian Federation
Yu. V. Kanishchev
Kursk State Medical University
Russian Federation
Russian Federation
G. A. Bondarev
Kursk State Medical University
Russian Federation
Russian Federation
P. M. Nazarenko
Kursk State Medical University
Russian Federation
Russian Federation
A. V. Polonikov
Kursk State Medical University
Russian Federation
Russian Federation
V. A. Lazarenko
Kursk State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Samgina T.A., Kolmykov D.I., Myasnyankina G.N., Gorbunov S.M., Azarova I.E., Kanishchev Yu.V., Bondarev G.A., Nazarenko P.M., Polonikov A.V., Lazarenko V.A. Contribution of risk factors in the development of chronic pancreatitis in carriers of rs213950 CFTR. Medical Genetics. 2021;20(2):21-26. (In Russ.) https://doi.org/10.25557/2073-7998.2021.02.21-26
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