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Медицинская генетика

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Неоцентромеры

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Аннотация

Центромера - фундаментальная структура, необходимая для поддержания стабильности генома. Центромерные районы хромосом характеризуются наличием альфа-сателлитной ДНК и белков центромерного комплекса, включая центромерный протеин A - CENP-A (centromere protein-A), которые, в свою очередь, определяют сборку кинетохора. Неоцентромеры - это новые, эктопические, сайты формирования функционально активного кинетохора в районах хромосом, не содержащих высокоповторенную ДНК, возникающие вследствие хромосомных перестроек. Феномен репозиции центромеры и сохранения неоцентромер в популяции является важным механизмом в видообразовании. В обзоре обсуждается значимость неоцентромер в цитогенетике целовека и эволюции хромосом.

Об авторе

Н. В. Шилова
Федеральное государственное бюджетное научное учреждение «Медико-генетический научный центр»
Россия


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Для цитирования:


Шилова Н.В. Неоцентромеры. Медицинская генетика. 2016;15(11):3-8.

For citation:


Shilova N.V. Neocentromeres. Medical Genetics. 2016;15(11):3-8. (In Russ.)

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