Increased methylation of gene promoters in the trophoblast of spontaneous miscarriages with trisomy 16
Abstract
An increased level of abnormal epigenetic regulation of gene expression in the trophoblast of spontaneous miscarriages with trisomy 16 was found. Among the hypermethylated genes, the group of genes of secreted proteins was significantly enriched, and a significant number of genes encoded receptors and transcription factors. Hypermethylation of the identified genes is a potential cause of death of embryos with trisomy 16 in the early stages of development.
About the Authors
S. A. Vasilyev
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences; National Research Tomsk State University
Russian Federation
Russian Federation
E. N. Tolmacheva
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
O. Yu. Vasilyeva
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
T. V. Nikitina
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
E. A. Sazhenova
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
A. V. Markov
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences; National Research Tomsk State University
Russian Federation
Russian Federation
E. S. Serdukova
National Research Tomsk State University
Russian Federation
Russian Federation
I. N. Lebedev
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
References
1. Tolmacheva E.N., Kashevarova A.A., Skryabin N.A., Lebedev I.N. Epigenetic effects of trisomy 16 in human placenta. Molecular Biology. 2013; 47(3): 373-381.
Review
For citations:
Vasilyev S.A., Tolmacheva E.N., Vasilyeva O.Yu., Nikitina T.V., Sazhenova E.A., Markov A.V., Serdukova E.S., Lebedev I.N. Increased methylation of gene promoters in the trophoblast of spontaneous miscarriages with trisomy 16. Medical Genetics. 2020;19(12):71-72. (In Russ.)
Views:
364
Email this article 