Epigenetic modifications of the X chromosome in families with miscarriage
https://doi.org/10.25557/2073-7998.2020.11.81-82
Abstract
Skewed inactivation of the X chromosome is characteristic for women with recurrent pregnancy loss and spontaneous abortions with a karyotype 46,XX. Skewed X-inactivation in spontaneous abortion is more often associated with the asymmetric inactivation in the mother.
About the Authors
E. N. Tolmacheva
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
E. A. Sazhenova
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
T. V. Nikitina
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
E. A. Fonova
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
M. E. Lopatkina
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
L. A. Zatula
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
I. N. Lebedev
Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
References
1. Sui Y., Chen Q., Sun X. Association of skewed X chromosome inactivation and idiopathic recurrent spontaneous abortion: a systematic review and meta-analysis. Reprod Biomed Online. 2015 Aug;31(2):140-8. doi: 10.1016/j.rbmo.2015.05.007.
2. Allen R.C., Zoghbi H.Y., Moseley A.B., Rosenblatt H.M., Belmont J.W. Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. Am J Hum Genet. 1992 Dec;51(6):1229-1239.
Review
For citations:
Tolmacheva E.N., Sazhenova E.A., Nikitina T.V., Fonova E.A., Lopatkina M.E., Zatula L.A., Lebedev I.N. Epigenetic modifications of the X chromosome in families with miscarriage. Medical Genetics. 2020;19(11):81-82. (In Russ.) https://doi.org/10.25557/2073-7998.2020.11.81-82
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