STUDY OF THE ROLE OF POLYMORPHISM OF GENE OF HAEMOSTASIS SYSTEM IN OCCURRENCE OF PRETERM BIRTH AMONG WOMEN OF UZBEK POPULATION
https://doi.org/10.1234/XXXX-XXXX-2015-5-37-41
Abstract
There has been performed analysis of the presence of mutagenic allele «1691А» gene FV Leiden and C677T gene MTGFR among the women with preterm labor. The carriers of mutant allele «1691А» in the hetero- or homozygous state among the women with preterm labors accounted for 8,5% that corresponded to 4,5 fold increase of the risk factor for development of venous thrombosis in comparison with control group (OR = 4.64; 95% CI 0.98—22.02). Differences in the frequency of prevalence of heterozygous variant of polymorphism C677T gene MTGFR between general groups of women with preterm labor and controls had statistic unreliable character. However, the carrying of the homozygous allele of this marker defined more than 4-fold increase in risk of the development of the venous thrombosis in comparison with control group (OR = 4.08: 95%CI 0,05—19,7), that indicated about participation of this marker in the development of venous thrombosis.
About the Authors
N. I. Lubchich
Republican specialized scientific-practice medical center of obstetrics and gynecology, Tashkent
Uzbekistan
Uzbekistan
100124 Mirzo Ulugbek street 132a
K. T. Boboev
Scientific-research institute of hematology and hemotransfusiology
Uzbekistan
100059, Usman Nasir street 138, Tashkent
Uzbekistan
100059, Usman Nasir street 138, Tashkent
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Review
For citations:
Lubchich N.I., Boboev K.T. STUDY OF THE ROLE OF POLYMORPHISM OF GENE OF HAEMOSTASIS SYSTEM IN OCCURRENCE OF PRETERM BIRTH AMONG WOMEN OF UZBEK POPULATION. Medical Genetics. 2015;14(5):37-41. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2015-5-37-41
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