Семейная средиземноморская лихорадка и беременность: литературный обзор
https://doi.org/10.25557/2073-7998.2020.11.4-12
Аннотация
В обзоре обобщается текущая информация о влиянии семейной средиземноморской лихорадки (ССЛ) и ее лечения на исходы беременности, анализируется вопрос гипотетической тератогенности колхицина. В случае резистентности/непереносимости колхицина обсуждается возможность использования других лекарственных средств во время беременности, в том числе, генно-инженерных биологических препаратов, среди которых при ССЛ наиболее предпочтительны ингибиторы интерлейкина 1. Представлена эволюция взглядов на необходимость проведения пренатальной диагностики хромосомных аномалий плода пациенткам с ССЛ, получающим колхицин во время зачатия и беременности, а также в тех случаях, когда колхицинотерапия проводилась мужьям во время зачатия их женами. Акцент сделан на аспектах безопасности терапии, основные положения которых представлены в клинических рекомендациях по лечению ССЛ Европейской антиревматической лиги (EULAR,2016). Согласно этим рекомендациям, прием колхицина не должен быть прекращен во время зачатия, беременности или лактации; имеющаяся на сегодняшний день доказательная база не подтверждает необходимость выполнения амниоцентеза.
Ключевые слова
семейная средиземноморская лихорадка (ССЛ),
ген MEFV,
беременность,
колхицин,
тератогенез,
амниоцентез,
роды
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Рецензия
Для цитирования:
Соцкий П.О. Семейная средиземноморская лихорадка и беременность: литературный обзор. Медицинская генетика. 2020;19(11):4-12. https://doi.org/10.25557/2073-7998.2020.11.4-12
For citation:
Sotskiy P.O. Familial Mediterranean Fever (FMF) and Pregnancy: Literature Review. Medical Genetics. 2020;19(11):4-12. (In Russ.) https://doi.org/10.25557/2073-7998.2020.11.4-12
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