The composition of the bacterial microbiome in the sputum of patients with lung cancer and the assessment of its effect on clastogenic effects in blood lymphocytes

Abstract

The impact of qualitative and quantitative changes in the composition of the bacterial microbiome in the sputum of 17 patients with lung cancer and 17 control donors on the parameters of somatic cell cytogenetic homeostasis was first assessed. Donors with high frequencies of chromosomal aberrations (CA) over 3.5 % had a significant decrease in the microbiome of the genera Prevotella, Selenomonas, Veillonella, as well as an increase in representatives of the genus Kocuria compared to donors with a low level of CA in lymphocytes. At the species level, differences were found in the contents of Anaerosinus glycerini, Selenomonas bovis, Actinomyces hyovaginalis, Granulicatella balaenopterae and Clostridium bolteae. Moreover, only the latter species was represented more often in the sputum of donors with high levels of CA, the remaining 4 types of bacteria were significantly more likely to be present in the sputum of donors with a low level of mutations in lymphocytes.