The effect of ADAMTS1, RBFOX2, THBS1 and WHSC1 gene expression on the formation of a radiation-induced cellular response
Abstract
In this study, we investigated the cell survival, the DNA repair foci level and the radiation-induced micronuclei frequency in the model systems in vitro and in the human peripheral blood lymphocytes with differential expression of ADAMTS1, RBFOX2, THBS1 and WHSC1 genes. The results indicate the potential opportunity of using these genes expression level to identify the individuals with increased radiosensitivity.
About the Authors
R. R. Savchenko
Research Institute of Medical Genetics, Tomsk National Research Medical Center of Russian Academy of Science
Russian Federation
Russian Federation
S. A. Vasilyev
Research Institute of Medical Genetics, Tomsk National Research Medical Center of Russian Academy of Science
Russian Federation
Russian Federation
V. S. Fishman
Institute of Cytology and Genetics
Russian Federation
Russian Federation
E. S. Sukhikh
Tomsk Regional Oncology Center
Russian Federation
Russian Federation
O. V. Gribova
Cancer Research Institute, Tomsk National Research Medical Center of Russian Academy of Science
Russian Federation
Russian Federation
Z. A. Startseva
Cancer Research Institute, Tomsk National Research Medical Center of Russian Academy of Science
Russian Federation
Russian Federation
A. A. Murashkina
National Research Tomsk State University
Russian Federation
Russian Federation
A. V. Dorofeeva
Siberian State Medical University
Russian Federation
Russian Federation
D. M. Shunkova
Siberian State Medical University
Russian Federation
Russian Federation
I. N. Lebedev
Research Institute of Medical Genetics, Tomsk National Research Medical Center of Russian Academy of Science
Russian Federation
Russian Federation
Review
For citations:
Savchenko R.R., Vasilyev S.A., Fishman V.S., Sukhikh E.S., Gribova O.V., Startseva Z.A., Murashkina A.A., Dorofeeva A.V., Shunkova D.M., Lebedev I.N. The effect of ADAMTS1, RBFOX2, THBS1 and WHSC1 gene expression on the formation of a radiation-induced cellular response. Medical Genetics. 2020;19(9):85-87. (In Russ.)
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