The study of paraquat genotoxicity by bacterial lux-biosensors

Abstract

It has been shown that paraquat (1,1-dimethyl-4,4 dipyridylium dichloride) induces luminescence of biosensors carrying the promoters of the soxS and katG genes that specifically react to the superoxide anion radical and hydrogen peroxide. The antioxidants glutathione and acetylcysteine reduced the level of biosensor luminescence and DNA breaks.