Molecular phenotype of bronchial asthma in combination with arterial hypertension
Abstract
Associations of eQTL SNPs of the TLR4, CAT, IL10, ADRB2, CST3, ICAM1, IRF6, NFKB1, PNP, SELL, SPP1, SMC2, SERPINA1, IL2RB, HSPA4, FOS, NT5C2, BHLHE40 genes with bronchial asthma, arterial hypertension and the comorbidity of these diseases were studied. As a results association of alleles, genotypes, and haplotypes formed by individual SNPs of TLR4, CAT, ANG, and RNASE4 genes with comorbidity of asthma and hypertension have been established which differ from SNPs associated with “isolated” asthma and arterial hypertension.
About the Authors
E. Yu. Bragina
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
I. A. Goncharova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
M. B. Freidin
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
I. Zh. Zhalsanova
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
D. E. Gomboeva
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
O. Yu. Bushueva
Kursk State Medical University
Russian Federation
Russian Federation
A. V. Polonikov
Kursk State Medical University
Russian Federation
Russian Federation
M. S. Nazarenko
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
A. V. Panasenko
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
V. P. Puzyrev
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
Russian Federation
Review
For citations:
Bragina E.Yu., Goncharova I.A., Freidin M.B., Zhalsanova I.Zh., Gomboeva D.E., Bushueva O.Yu., Polonikov A.V., Nazarenko M.S., Panasenko A.V., Puzyrev V.P. Molecular phenotype of bronchial asthma in combination with arterial hypertension. Medical Genetics. 2020;19(8):87-89. (In Russ.)
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