Differences in the level of inbreeding in populations of Dagestan: analysis of runs of homozygosity

Abstract

The genomic data analysis (~907750 autosomal SNPs) allowed us to estimate the inbreeding level based on the analysis of runs of homozygosity (Froh) in the group of 518 people from 23 indigenous Dagestan peoples. As a result, the number and total length of ROH, as well as the FROH coefficient, show a significant diversity in the indigenous Dagestan populations both inside and between them. One of the highest values of the inbreeding coefficient (FROH> 1.5Mb) is observed for the Ginukhs, Gunzibians, Akhvakhs, Bezhtins, and Tsez, as compared with the other world populations.