Polymorphic variants of DNA repair enzyme genes in the pathogenesis of lung cancer in women

Abstract

In the presented «case-control» study 540 residents of the Kemerovo Region subject to age, sex and smoking status were included. We formed two groups: 1) «Case» - 270 newly diagnosed lung cancer patients undergoing a medical treatment in the Kemerovo Regional Oncology Center; 2) «Control» - 268 healthy donors of the Kemerovo Regional Center of Blood Transfusion. Statistical analysis were performed using SNPstats (http://bioinfo.iconcologia.net/SNPstats), «Statistica 10.0» (StatSoft, Inc., USA). A significant association obtained between the APEX1 (rs1130409), hOGG1 (rs1052133), XRCC1 (rs25489), АТМ (rs18015), XPC (rs2228001)) and lung cancer.