The study of gene polymorphisms of the IL-17 family in patients with gastric cancer of the West Siberian region

Abstract

The analysis of IL-17A G197A and IL-17FA7488G in 150 patients with gastric cancer and 103 healthy. The studied groups are comparable by gender and age. Among the controls, the genotype distribution for each SNP is in Hardy-Weinberg equilibrium. (p> 0.05). The frequencies of IL-17F A7488G genotypes in cases (GG - 38.7%; GA - 39.3% and AA, 22%) significantly differed from those in the control (GG, 16.5%; GA, 60.2% and AA, 23.3%). The genotypes of IL-17A197 in cases also differed from those in the control (AA 40.7%; AG, 48.7%; GG, 10.6% and AA 17.5%; AG, 70.8%; GG, 11.7%, respectively). Our data may indicate that the genotypes GG, IL-17F A7488G and AA, IL-17A197 are associated with a risk of developing gastric cancer.