Association of a combination of alleles and genotypes of polymorphic variants of matrix metalloproteinase genes and their tissue inhibitors genes with a risk of developing of gastric cancer
Abstract
The analysis of the frequency distribution of alleles/genotypes of polymorphic loci rs1799750 and rs494379 of the MMP1 gene, rs2285053 of the MMP2 gene, rs3025058 of the MMP3 gene, rs3918242 and rs17576 of the MMP9 gene, rs2276109 of the MMP12 gene, rs8179090 of the TIMP2 gene and rs9619311 of the TIMP3 gene in 314 patients with gastric cancer, as well as in 339 healthy individuals from the Republic of Bashkortostan. Using the APSampler algorithm were identified combinations of alleles/genotypes associated with increased and reduced risk of developing the disease.
About the Authors
L. F. Gallyamova
Bashkir State University
Russian Federation
Russian Federation
A. Kh. Nurgalieva
Bashkir State University
Russian Federation
Russian Federation
Sh. M. Khusnutdinov
Republic Clinical Oncological Center of Bashkortostan Republic
Russian Federation
Russian Federation
D. D. Sakaeva
Bashkir State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
E. K. Khusnutdinova
Institute of Biochemistry and Genetics, Ufa Federal Research Centre, Russian Academy of Sciences
Russian Federation
Russian Federation
Review
For citations:
Gallyamova L.F., Nurgalieva A.Kh., Khusnutdinov Sh.M., Sakaeva D.D., Khusnutdinova E.K. Association of a combination of alleles and genotypes of polymorphic variants of matrix metalloproteinase genes and their tissue inhibitors genes with a risk of developing of gastric cancer. Medical Genetics. 2020;19(6):70-72. (In Russ.)
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