Expression of FN1 and PDGFRβ in lymph nodes metastasis of breast cancer

Abstract

The most serious complication of breast cancer (BC) is metastasis, which causes more than 80% of all deaths from BC. The process of lymph nodes metastasis is not well understood. 47 paired frozen breast tissue samples were collected. All patients have no radiation therapy and chemotherapy. We studied the expression of two genes - FN1 and PDGFRβ - for the investigation of their relationship to lymph nodes metastasis. Expression of the FN1 and PDGFRβ genes showed an association with the risk of early metastasis (p = 0.012 and 0.03, correspondently). The relative risk (RR) for FN1 was RR = 1.5, 95% CI 1,1-1,9, and for PDGFRβ RR = 2.4, 95% CI 1,1-5,2.