Estimation of prognostic value of ABC transporter genes expression changes during neoadjuvant chemotherapy in non-small cell lung cancer
https://doi.org/10.1234/XXXX-XXXX-2016-5-52-55
Abstract
The use of neoadjuvant chemotherapy in the treatment of patients with non-small cell lung cancer can reduce the tumor size, increase ablastics operations, as well as to plan carrying out post-operative chemotherapy. But one of the important reasons for the ineffectiveness of chemotherapy is chemoresistance due to the expression of ABC-transporter genes ( ABCB1, ABCC1, ABCC2, ABCC5, ABCG1, ABCG2 and gene metabolism GSTP1 ). Thus, the aim was to study the expression of ABC genes during chemotherapy. As a result, it was found that the expression of genes correlated with chemoresistance weakly basic clinical and morphological parameters. But it was found that the direction of change in gene expression ABCB1 , increase or decrease, associated with survival rates.
About the Authors
M. M. Tsyganov
Tomsk Саnсеr Rеsеаrсh Institute; National Research Tomsk State University
Russian Federation
Russian Federation
I. V. Deryusheva
Siberian State Medical University
Russian Federation
Russian Federation
E. O. Rodionov
Tomsk Саnсеr Rеsеаrсh Institute
Russian Federation
Russian Federation
M. K. Ibragimova
Tomsk Саnсеr Rеsеаrсh Institute; National Research Tomsk State University
Russian Federation
Russian Federation
S. V. Miller
Tomsk Саnсеr Rеsеаrсh Institute
Russian Federation
Russian Federation
N. V. Litvyakov
Tomsk Саnсеr Rеsеаrсh Institute; National Research Tomsk State University
Russian Federation
Russian Federation
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Review
For citations:
Tsyganov M.M., Deryusheva I.V., Rodionov E.O., Ibragimova M.K., Miller S.V., Litvyakov N.V. Estimation of prognostic value of ABC transporter genes expression changes during neoadjuvant chemotherapy in non-small cell lung cancer. Medical Genetics. 2016;15(5):52-55. (In Russ.) https://doi.org/10.1234/XXXX-XXXX-2016-5-52-55
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